Cosmetics – Do you know why many different chemical compounds found in creams, cosmetics, and other topical consumer products trigger allergic reactions in the skin? The way some chemicals displace natural fat-like molecules — called lipids — in skin cells may be the culprit, suggests new research.

This discovery, published in the journal Science Immunology, raises the possibility that allergic contact dermatitis could be stopped by applying competing lipids to the skin to displace those triggering the immune reaction.

Currently, the only way to stop allergic contact dermatitis is to identify and avoid contact with the offending chemical. Topical ointments can help sooth the rashes, which usually clear up in less than a month.

In severe cases, physicians may prescribe oral corticosteroids, anti-inflammatory agents that suppress the immune system, increasing the risk of infections and other side effects. An allergic reaction begins when the immune system’s T cells recognise a chemical as foreign. T cells do not directly recognise small chemicals, and research suggests that these compounds need to undergo a chemical reaction with larger proteins in order to make themselves visible to T cells.

“However, many small compounds in skincare products that trigger allergic contact dermatitis lack the chemical groups needed for this reaction to occur,” said study co-leader Annemieke de Jong, Assistant Professor of dermatology at Columbia University Vagelos College of Physicians and Surgeons in New York.

“These small chemicals should be invisible to T cells, but they’re not,” De Jong said.

De Jong and her colleagues suspected that CD1a, a molecule that is abundant on Langerhans cells (immune cells in the skin’s outer layer), might be responsible for making these chemicals visible to T cells.

In the current study, conducted with human cells in tissue culture, the researchers found that several common chemicals known to trigger allergic contact dermatitis were able to bind to CD1a molecules on the surface of Langerhans cells and activate T cells.

These chemicals included Balsam of Peru and farnesol, which are found in many personal care products, such as skin creams, toothpaste, and fragrances.

Within Balsam of Peru, the researchers identified benzyl benzoate and benzyl cinnamate as the chemicals responsible for the reaction, and overall they identified more than a dozen small chemicals that activated T cells through CD1a.

Walking, cycling to work is associated with fewer heart attacks in adults, say researchers, adding that could provide important health benefits.

According to the study published in the European Journal of Preventive Cardiology, in areas where walking or cycling to work were more common in 2011, the incidence of heart attacks in UK decreased for both men and women across the following two years.

“Our study at the University of Leeds shows that exercise as a means of commuting to work is associated with lower levels of heart attack. The benefits of regular exercise are numerous and we support initiatives to help everyone become and stay active,” said study co-author and Olympic-medal winning triathlete Alistair Brownlee.

The study looked at the 2011 UK Census data, which included 43 million people aged 25-74 years employed in England, and found that 11.4 per cent were active commuters. Walking was more popular than cycling (8.6 per cent vs. 2.8 per cent).

Active commuting was defined as people who reported their main mode of transport to work as either ‘bicycle’ or ‘on foot’ in the UK Census.

Rates of active travel varied significantly between local authorities across England, with as few as five per cent of people walking or cycling to work in some authorities, compared to as many as 41.6 per cent in other areas.

There was also a sex difference for active travel in the 2011 Census data, with more men cycling to work than women (3.8 per cent vs. 1.7 per cent), but more women walking to work than men (11.7 per cent vs. 6.0 per cent).

The researchers acknowledged that the big risk factors for heart disease are a lack of exercise, being overweight, smoking and diabetes.

After adjusting for these, the researchers found that active commuting was linked with additional health benefits in some cases.

For women who walked to work there was an associated 1.7 per cent reduction in heart attacks the following year. For men who cycled to work there was also an associated 1.7 per cent reduction in heart attacks the following year, the study said.

“Whilst we cannot conclusively say that active travel to work lowers the risk of heart attack, the study is indicative of such a relationship,” said study lead author Chris Gale, Professor at the University of Leeds.

“The effect of active commuting is fairly modest when compared with the stronger determinants of cardiovascular health such as smoking, obesity, diabetes, and regular exercise. However, this study clearly suggests that exercising on the way to work has the potential to bring nationwide improvements to health and wellbeing,” Gale said.

Shakes Recipes  – There are no cooking pressure or extraordinary aptitudes required to make a helpful, convenient, and simple and useful shakes formula. Shakes are useful for competitors as well as everybody who want to stay in shape and dynamic. Rather than going to get some R&R or shakes that may contain a lot of sugars and calories from stores after an exercise, it will be smarter to make a shape that will keep you in a decent healthy condition. It is likewise bravo to get blenders for shakes with the goal that they become advantageous and simple to make.

The following are the top valuable shakes plans that can assist you with keeping up your fit.

Berry Super Shake

One of the manners in which you can stay in shape is going for helpful shakes formula. The Very Berry Super Shake won’t just furnish you with nourishment that will assist you with staying in shape yet it will make you remain sound and hyperactive. This shake is wealthy in protein, phytonutrients, probiotics, and sound sugars.

It very well may be taken as breakfast, lunch or supper previously or after an exercise. For you to get a smooth formula, you will require a blender that is made only for shakes.

You can get this shake formula by mixing 12 oz. water, ½ cup plain low-fat yogurt, 1 cup spinach, 2 scoops vanilla protein powder, 2 cups solidified blended berries, 1 tbsp. pecans, 1tbsp ground flaxseed together. 500 calories, 11g fat, 54g carbs, 14g fiber, and 57g protein will be all the source if the wellspring of liquid is water rather than milk or yogurt.

2. Strawberry Banana Shake

The Strawberry Banana Shake is a decent formula that will be gainful in causing you to keep up your wellness. This exemplary protein shake will give you an additional fiber and heart-solid omega-3 fats on the off chance that you add ground flax to it.

Getting a decent blender for shakes will facilitate your pressure and permit you to amass in working more beneficial fats into your eating regimen. The strawberry and banana purpose is a decent wellspring of Omega-3s.

You can get this by mixing together the accompanying: 12 oz. water, milk, or yogurt, 2 scoops vanilla or strawberry seasoned protein powder, 1 banana, 1 cup of spinach, 1 cup of solidified strawberries, 2tbsp of ground flax. 490 calories, 55g protein, 47g carbs, 9g fat, 11g fiber will be gotten if water is utilized as a wellspring of liquid rather than milk or yogurt.

3. Apple and Great Grains Shake

The flavor of this brilliant shake is like that of crusty fruit-filled treat in a glass. In spite of the fact that, its absolutely impossible you can get 58 grams of protein in a cut of celebrated sweet. Most blender for shakes will have the option to deal with beating an apple. The skin will be left to give all that anyone could need phytonutrients.

To get this superb shake, you should mix together 12oz water, milk, 1 apple (with evacuated center and cut into wedges), 2 scoop vanilla seasoned protein, 2tbsp of almonds, 1 cup of spinach, Cinnamon, and ¼ cup of uncooked oats.

4. Chocolate, Peanut Butter, and Banana Shake

This is additionally a decent shake that keeps the body in that ideal and wanted fit. Its absolutely impossible you will realize that this delicious shake contains a cup of spinach. It likewise contains chocolate, nutty spread, and banana. What you have to get this shake are 12 oz. water, milk or yogurt, 1 banana, 1 cup of spinach, 2 scoops chocolate seasoned protein powder, 2 tbsp of normal nutty spread, 1tbsp cacao nibs or dull cocoa powder.

5. Dr. Mike’s Power Shake

The Walnuts and Flax right now will give you enough measure of omega-3 fats, which is useful for your cerebrum and heart. it tends to be taken after a careful exercise and it makes you sound, keep the body in an ideal shape and totally keep up your wellness.

To get the Dr. Mike’s Power Shake, mix the accompanying: ¼ cup low fat curds, 1 scoop vanilla protein powder, 1 cup blueberries (crisp or solidified), 1½ cups water, 2tbsp flaxseed supper, 2tbsp pecans, 3 ice 3D shapes.

6. Superfood Shake

The Superfood Shake will support athletic execution, muscle recuperation and help in looking after fit. It is a decent wellspring of supplements in profoundly hued foods grown from the ground like beets and fruits. In the event that you need to get make this extraordinary shake, at that point mix together 8oz water, ½ cup hacked crude beets, ½ cup solidified blueberries, ½ cup solidified fruits, ½ banana, ½ cup solidified strawberries, 1 scoop chocolate whey protein,1tbsp ground flaxseed.

7. Vanilla Pumpkin Pie Shake

This formula will give you something altogether not quite the same as the regular old formula you are utilized to. Going for shakes with a sample of pumpkin pie, has an extraordinary taste as well as supplement stuffed. Aside from the sweet taste, it is additionally an extraordinary wellspring of Vitamin, particularly Vitamin A, which is appropriate for acceptable sight, skin, and substitution of destroyed tissues.

You can accomplish this by relying upon a blender for shakes by mixing together 12oz water, milk, or yogurt, 1tbsp of pecans, 1tbsp of ground flax, ¾ cup of pureed pumpkin, ½ cup of uncooked oats, 2 scoops vanilla seasoned protein powder, Cinnamon and vanilla concentrate to taste Ice varying.

8. Tropical Power Shake

The Tropical Powder Shakes resembles a pina colada, yet it ought to be blended in with 58 grams of protein and a cup of spinach to get the correct shake. To get this, mix the accompanying together: 12oz water, milk, or yogurt, ½ banana, ½ cup plain yogurt or veggie lover elective, 1 cup of pineapple, 1tbsp of ground flax, 1 cup of spinach, 2 scoops vanilla enhanced protein powder, and 2tbsp of unsweetened coconut chips.

9. Prepared Apple Shake

Prepared Apple shake will give you the basic supplement you require after an exercise as the sesame seeds right now include unforeseen flavor, in addition to an aiding of magnesium and selenium.

,p>To get the formula you can make a blend of 12oz water, milk, or yogurt, 1 apple, center expelled, and cut into wedges, 2 scoops vanilla enhanced protein powder, 1 cup of spinach, 1tbsp of ground flax, 1tbsp of sesame seeds, 1tbsp of almonds, Cinnamon to taste Ice varying. 

10. Chocolate Cherry Awesomeness Shake

As indicated by disclosures by late research, Cherries can help in facilitating irritation after a careful exercise. This shake is an ideal recuperation shake to assist you with keeping up your wellness. Mix the accompanying: 12 oz. water, 1 cups of spinach, 1tbsp of pecans, milk, or yogurt, 2 cups of sweet dull fruits (the pits ought to be removed),2 scoops chocolate seasoned protein powder, 1 tbsp. cacao nibs or dim cocoa powder, 1 tbsp. ground flax.